Potassium Cation → Tert-butyl 4-ethynyl-4-hydroxypiperidine-1-carboxylate

HRID 1114669Notes

Reaction equation

HRID 1114669 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([C:14]#[C:15][Si:16]([CH3:17])([CH3:18])[CH3:19])([OH:20])[CH2:12][CH2:13]1.[C:21](=[O:22])([O-:23])[O-:24].[CH3:27][OH:28].[K+:25].[K+:26]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([C:14]#[CH:15])([OH:20])[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 813Potassium Cation2×HCID 887MethanolHCID 19660Carbonate IonHCID 108039811,1-Dimethylethyl 4-hydroxy-4-[(trimethylsilyl)ethynyl]-1-piperidinecarboxylate

Product 1

HCID 18366117Tert-butyl 4-ethynyl-4-hydroxypiperidine-1-carboxylate

Sources & evidence

ORD record
ord-0e946950c5194a13ae0844719657b4f8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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