7-Bromo-4-(2-chlorophenyl)-9-hydroxy-1H-[1]benzofuro[3,2-e]isoindole-1,3(2H)-dione → 4-(2-Chlorophenyl)-9-hydroxy-7-vinyl-1H-[1]benzofuro[3,2-e]isoindole-1,3(2H)-dione

Participants

Reaction Steps

Reaction of (862) prepared as described in example 443 with tributylvinyltin using the procedure described in example 309 gave (863) (79%). 1H NMR δ [(CD3)2SO] 9.80 (s, 1H), 8.04 (d, J=2.7 Hz, 1H), 7.91 (s, 1H), 7.56 (d, J=8 Hz, 1H), 7.45 (m, 3H), 7.2 (d, J=2.5 Hz, 1H), 6.96 (dd, J=18,1 Hz, 1H), 6.25 (d, J=18 Hz, 1H), 5.52 (d, J=11 Hz, 1H). MH−:390,388.

Provenance & Evidence