Tert-butyl 4-(2-hydroxyphenyl)piperazine-1-carboxylate → 4-[2-(1-Acetyl-piperidin-3-yloxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

HRID 1115673Notes

Reaction equation

HRID 1115673 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15]([OH:20])[cH:16][cH:17][cH:18][cH:19]2)[CH2:12][CH2:13]1.[OH:21][CH:22]1[CH2:23][N:24]([C:28]([CH3:29])=[O:30])[CH2:25][CH2:26][CH2:27]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15]([O:20][CH:22]3[CH2:23][N:24]([C:28]([CH3:29])=[O:30])[CH2:25][CH2:26][CH2:27]3)[cH:16][cH:17][cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 11543684Tert-butyl 4-(2-hydroxyphenyl)piperazine-1-carboxylateHCID 218970301-(3-Hydroxypiperidin-1-yl)ethan-1-one

Product 1

HCID 694197504-[2-(1-Acetyl-piperidin-3-yloxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-7451527b56cf4f388a3eee32bf41222b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…