Acetic Acid → Nebivolol Impurity 32

HRID 1116059Notes

Reaction equation

HRID 1116059 reaction equation
[CH3:20][C:21](=[O:22])[OH:23].[F:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[O:8][CH:7]([CH:12]1[O:13][C:14]([CH3:17])([CH3:18])[O:15][CH2:16]1)[CH2:6][CH2:5]2.[OH2:19]>>[F:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[O:8][CH:7]([CH:12]([OH:13])[CH2:16][OH:15])[CH2:6][CH2:5]2

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 962WaterHCID 673369882-(2,2-dimethyl-1,3-dioxolan-4-yl)-6-fluoro-3,4-dihydro-2H-chromene

Product 1

HCID 44631567Nebivolol Impurity 32

Sources & evidence

ORD record
ord-72e97b7cafc74650a7faac36103f4de5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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