Potassium Cation → N-(4-ethynyl-5-(3-(trifluoromethyl)phenyl)thiazol-2-yl)-2,6-difluorobenzamide

HRID 1116451Notes

Reaction equation

HRID 1116451 reaction equation
[CH3:47][OH:48].[Cl:49][CH2:50][Cl:51].[F:1][c:2]1[c:3]([C:4](=[O:5])[NH:6][c:7]2[s:8][c:9](-[c:14]3[cH:15][c:16]([C:20]([F:21])([F:22])[F:23])[cH:17][cH:18][cH:19]3)[c:10]([CH:12]=[O:13])[n:11]2)[c:24]([F:28])[cH:25][cH:26][cH:27]1.[K+:41].[K+:42].[N+:29](=[C:31]([P:30](=[O:32])([O:33][CH3:34])[O:35][CH3:36])[C:37](=[O:38])[CH3:39])=[N-:40].[O-:43][C:44]([O-:45])=[O:46]>>[F:1][c:2]1[c:3]([C:4](=[O:5])[NH:6][c:7]2[s:8][c:9](-[c:14]3[cH:15][c:16]([C:20]([F:21])([F:22])[F:23])[cH:17][cH:18][cH:19]3)[c:10]([C:12]#[CH:31])[n:11]2)[c:24]([F:28])[cH:25][cH:26][cH:27]1

Participants

7

Reactant 6

HCID 813Potassium Cation2×HCID 887MethanolHCID 6344DichloromethaneHCID 19660Carbonate IonHCID 24765490HCID 24765490, compoundHCID 136023029(1E)-1-diazo-1-dimethoxyphosphorylpropan-2-one

Product 1

HCID 24765970N-(4-ethynyl-5-(3-(trifluoromethyl)phenyl)thiazol-2-yl)-2,6-difluorobenzamide

Sources & evidence

ORD record
ord-ed1cad089662447dbca682fb50096e8f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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