4-[[(3,4-Difluorophenyl)amino](4-fluorophenyl)methyl]piperidine → 1-[3-[(4-Chlorophenyl)sulfinyl]propyl]-N-(3,4-difluorophenyl)-alpha-(4-fluorophenyl)-4-piperidinemethanamine

HRID 1116667Notes

Reaction equation

HRID 1116667 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]([S:8](=[O:9])[CH2:10][CH2:11][CH2:12][Cl:13])[cH:6][cH:7]1.[F:14][c:15]1[cH:16][c:17]([NH:22][CH:23]([CH:24]2[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]2)[c:30]2[cH:31][cH:32][c:33]([F:36])[cH:34][cH:35]2)[cH:18][cH:19][c:20]1[F:21]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([S:8](=[O:9])[CH2:10][CH2:11][CH2:12][N:27]2[CH2:26][CH2:25][CH:24]([CH:23]([NH:22][c:17]3[cH:16][c:15]([F:14])[c:20]([F:21])[cH:19][cH:18]3)[c:30]3[cH:31][cH:32][c:33]([F:36])[cH:34][cH:35]3)[CH2:29][CH2:28]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 197720314-[[(3,4-Difluorophenyl)amino](4-fluorophenyl)methyl]piperidineHCID 197720711-(p-Chlorophenylsulfinyl)-3-chloropropane

Product 1

HCID 197719671-[3-[(4-Chlorophenyl)sulfinyl]propyl]-N-(3,4-difluorophenyl)-alpha-(4-fluorophenyl)-4-piperidinemethanamine

Sources & evidence

ORD record
ord-67d5961472144d6db365249a2cdb66ec
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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