Ethanol → N-(3-((4aS,7aS)-2-amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide

HRID 1116717Notes

Reaction equation

HRID 1116717 reaction equation
[C:1](=[O:2])([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[NH:9][C:10]1=[N:15][C:14]2([c:19]3[cH:20][c:21]([NH:26][C:27]([c:28]4[cH:29][cH:30][c:31]([F:34])[cH:32][n:33]4)=[O:35])[cH:22][cH:23][c:24]3[F:25])[CH:13]([CH2:12][S:11]1)[CH2:18][O:17][CH2:16]2.[CH3:43][CH2:44][OH:45].[OH2:42].[cH:36]1[cH:37][cH:38][n:39][cH:40][cH:41]1>>[NH2:9][C:10]1=[N:15][C:14]2([c:19]3[cH:20][c:21]([NH:26][C:27]([c:28]4[cH:29][cH:30][c:31]([F:34])[cH:32][n:33]4)=[O:35])[cH:22][cH:23][c:24]3[F:25])[CH:13]([CH2:12][S:11]1)[CH2:18][O:17][CH2:16]2

Participants

5

Reactant 4

HCID 702EthanolHCID 962WaterHCID 1049PyridineHCID 76550584N-[3-(2-benzamido-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl]-5-fluoropyridine-2-carboxamide

Product 1

HCID 57475760N-(3-((4aS,7aS)-2-amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide

Sources & evidence

ORD record
ord-74446c2d8ca84b14a0eff21a69b5078b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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