HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanoacetamide → HCID 178418929, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanoacetamide | HCID 7898 | — |
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Product | HCID 178418929 | HCID 178418929 | — |
Reaction Steps
Amine was generated by the condensation of ethylacetoacetate with cyanoacetamide followed by reaction with phosphorus oxychloride to provide 3-cyano-2,5-dihydroxy-4-methylpyridine. Hydrogenation with palladium dichloride gave the 3-cyano-4-methylpyridine which was hydrogenated with Raney nickel in ammonia and ethanol to afford the desired amine (J. Org. Chem. 1959, 25, 560.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07094909B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-3a88dd9b299e453abb8cca072f727e81 |
| Source note | uspto-grants-2006_08 |