HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → Dicyclohexylcarbodiimide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | (4R)-3-[(2S,3S)-2-hydroxy-3-(1H-indole-4-carbonylamino)-4-phenyl-butanoyl]-5,5-dimethyl-N-(o-tolylmethyl)thiazolidine-4-carboxamide | HCID 514529 | — |
| Product | Dicyclohexylcarbodiimide | HCID 10868 | — |
Reaction Steps
The synthesis of compounds with the general structure 27 is as follows. The boc-protected thiazolidine carboxylic acid 1 is converted to amino-ketones 26 with requisite grignard reagents 25 in the presence of oxalyl chloride. Final compounds 27 are obtained by a DCC-mediated coupling of 26 and 4 followed by deprotection of the P2 phenol. Final compounds were purified either by flash chromatography or preparative HPLC. Specific Method D
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07094909B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-d385b842dcb8486f8120e8156d84ee72 |
| Source note | uspto-grants-2006_08 |