Bromide ion → 2-((4-(1-Hydroxyethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-6-methylthieno[2,3-d]pyrimidin-4(3H)-one

HRID 1117224Notes

Reaction equation

HRID 1117224 reaction equation
[Br-:24].[CH3:1][c:2]1[cH:3][c:4]2[c:5]([n:6][c:7]([CH2:11][n:12]3[n:13][c:14]([C:19]([F:20])([F:21])[F:22])[c:15]([CH:17]=[O:18])[cH:16]3)[nH:8][c:9]2=[O:10])[s:23]1.[CH3:25][Mg+:26].[CH3:28][CH2:29][O:30][CH2:31][CH3:32].[OH2:27]>>[CH3:1][c:2]1[cH:3][c:4]2[c:5]([n:6][c:7]([CH2:11][n:12]3[n:13][c:14]([C:19]([F:20])([F:21])[F:22])[c:15]([CH:17]([OH:18])[CH3:25])[cH:16]3)[nH:8][c:9]2=[O:10])[s:23]1

Participants

6

Reactant 5

HCID 259Bromide ionHCID 962WaterHCID 3283Diethyl EtherHCID 866303971-((6-Methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)methyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehydeHCID 178477777HCID 178477777, compound

Product 1

HCID 665918052-((4-(1-Hydroxyethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-6-methylthieno[2,3-d]pyrimidin-4(3H)-one

Sources & evidence

ORD record
ord-142a0ad7cdeb47388e951a98c18d8c95
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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