Water → Methyl 1-[5-(morpholin-4-ylcarbonyl)-4-(trifluoromethyl)pyrimidin-2-yl]-1,2,3,4-tetrahydroquinoline-6-carboxylate
Reaction equation
[C:34](=[O:35])([O-:36])[O-:37].[CH3:40][c:41]1[cH:42][cH:43][cH:44][cH:45][cH:46]1.[Cl:1][c:2]1[n:3][cH:4][c:5]([C:12](=[O:13])[N:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)[c:6]([C:8]([F:9])([F:10])[F:11])[n:7]1.[Cs+:38].[Cs+:39].[NH:20]1[CH2:21][CH2:22][CH2:23][c:24]2[cH:25][c:26]([C:30](=[O:31])[O:32][CH3:33])[cH:27][cH:28][c:29]21.[O:49]=[C:50]([CH:51]=[CH:52][c:53]1[cH:54][cH:55][cH:56][cH:57][cH:58]1)[CH:59]=[CH:60][c:61]1[cH:62][cH:63][cH:64][cH:65][cH:66]1.[O:67]=[C:68]([CH:69]=[CH:70][c:71]1[cH:72][cH:73][cH:74][cH:75][cH:76]1)[CH:77]=[CH:78][c:79]1[cH:80][cH:81][cH:82][cH:83][cH:84]1.[O:85]=[C:86]([CH:87]=[CH:88][c:89]1[cH:90][cH:91][cH:92][cH:93][cH:94]1)[CH:95]=[CH:96][c:97]1[cH:98][cH:99][cH:100][cH:101][cH:102]1.[OH2:103].[Pd:47].[Pd:48]>>[c:2]1([N:20]2[CH2:21][CH2:22][CH2:23][c:24]3[cH:25][c:26]([C:30](=[O:31])[O:32][CH3:33])[cH:27][cH:28][c:29]32)[n:3][cH:4][c:5]([C:12](=[O:13])[N:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)[c:6]([C:8]([F:9])([F:10])[F:11])[n:7]1Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-5cf9e2144c714a28b9232ff3f932c4bb
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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