Bicarbonate Ion → N-(1,2,3,4-Tetrahydroisoquinolin-5-yl)-5-chloro-2,4-dimethoxybenzamide

HRID 111765Notes

Reaction equation

HRID 111765 reaction equation
[C:32](=[O:33])([OH:34])[O-:35].[Cl:1][c:2]1[c:3]([O:30][CH3:31])[cH:4][c:5]([O:28][CH3:29])[c:6]([C:7](=[O:8])[NH:9][c:10]2[c:11]3[c:16]([cH:17][cH:18][cH:19]2)[CH2:15][N:14]([C:20]([O:21][C:22]([CH3:23])([CH3:24])[CH3:25])=[O:26])[CH2:13][CH2:12]3)[cH:27]1.[Cl:37][CH2:38][Cl:39].[Na+:36]>>[Cl:1][c:2]1[c:3]([O:30][CH3:31])[cH:4][c:5]([O:28][CH3:29])[c:6]([C:7](=[O:8])[NH:9][c:10]2[c:11]3[c:16]([cH:17][cH:18][cH:19]2)[CH2:15][NH:14][CH2:13][CH2:12]3)[cH:27]1

Participants

5

Reactant 4

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 6344DichloromethaneHCID 186873951,1-Dimethylethyl 5-[(5-chloro-2,4-dimethoxybenzoyl)amino]-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Product 1

HCID 18687356N-(1,2,3,4-Tetrahydroisoquinolin-5-yl)-5-chloro-2,4-dimethoxybenzamide

Sources & evidence

ORD record
ord-47d2d9388bb44fb481dbfe89c8de722e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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