Pyridine → 6-Bromo-2-(bromomethyl)-3-fluoropyridine

HRID 1117860Notes

Reaction equation

[Br:5][c:6]1[cH:7][cH:8][c:9]([F:14])[c:10]([CH2:12][OH:13])[n:11]1.[Cl:21][CH2:22][Cl:23].[S:1]([Br:2])([Br:3])=[O:4].[cH:15]1[cH:16][cH:17][n:18][cH:19][cH:20]1>>[Br:3][CH2:12][c:10]1[c:9]([F:14])[cH:8][cH:7][c:6]([Br:5])[n:11]1

Participants

Reactant 4

HCID 1049Pyridine

HCID 6344Dichloromethane

HCID 68176Thionyl bromide

HCID 53485567(6-Bromo-3-fluoropyridin-2-yl)methanol

Product 1

HCID 866422856-Bromo-2-(bromomethyl)-3-fluoropyridine

Sources & evidence

ORD record: ord-337eda49c4e543428221f1f4a43c042d
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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