Carbamic acid,(3-amino-2',4'-difluoro[1,1'-biphenyl]-4-yl)-,1,1-dimethylethyl ester → {3-[3-(2-Cyano-pyridin-4-yl)-3-oxo-propionylamino]-2',4'-difluoro-biphenyl-4-yl}-carbamic acid tert.-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][c:8]1[c:9]([NH2:22])[cH:10][c:11](-[c:14]2[c:15]([F:21])[cH:16][c:17]([F:20])[cH:18][cH:19]2)[cH:12][cH:13]1)=[O:23].[C:24]([CH3:26])([CH3:27])([O:28][C:29](=[O:25])[CH2:30][C:31](=[O:32])[c:33]1[cH:34][c:35]([C:39]#[N:40])[n:36][cH:37][cH:38]1)[CH3:41]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][c:8]1[c:9]([NH:22][C:29](=[O:28])[CH2:30][C:31](=[O:32])[c:33]2[cH:34][c:35]([C:39]#[N:40])[n:36][cH:37][cH:38]2)[cH:10][c:11](-[c:14]2[c:15]([F:21])[cH:16][c:17]([F:20])[cH:18][cH:19]2)[cH:12][cH:13]1)=[O:23]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-d7a75496ceb44e5ea814ebd7b4d4cec6
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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