Potassium Cation → N-(2,4-difluorophenyl)-2-(6-(4-(2-fluorophenyl)piperazine-1-carbonyl)-5-methyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)acetamide

HRID 1118633Notes

Reaction equation

HRID 1118633 reaction equation
[CH3:46][C:47]#[N:48].[Cl:33][CH2:34][C:35](=[O:36])[NH:37][c:38]1[c:39]([F:45])[cH:40][c:41]([F:44])[cH:42][cH:43]1.[F:1][c:2]1[c:3]([N:8]2[CH2:9][CH2:10][N:11]([C:14](=[O:15])[c:16]3[c:17]([CH3:26])[c:18]4[c:19]([n:20][cH:21][nH:22][c:23]4=[O:24])[s:25]3)[CH2:12][CH2:13]2)[cH:4][cH:5][cH:6][cH:7]1.[K+:27].[K+:28].[O-:29][C:30]([O-:31])=[O:32]>>[F:1][c:2]1[c:3]([N:8]2[CH2:9][CH2:10][N:11]([C:14](=[O:15])[c:16]3[c:17]([CH3:26])[c:18]4[c:19]([n:20][cH:21][n:22]([CH2:34][C:35](=[O:36])[NH:37][c:38]5[c:39]([F:45])[cH:40][c:41]([F:44])[cH:42][cH:43]5)[c:23]4=[O:24])[s:25]3)[CH2:12][CH2:13]2)[cH:4][cH:5][cH:6][cH:7]1

Participants

6

Reactant 5

HCID 813Potassium Cation2×HCID 6342AcetonitrileHCID 19660Carbonate IonHCID 7358542-chloro-N-(2,4-difluorophenyl)acetamideHCID 160032576-(4-(2-fluorophenyl)piperazine-1-carbonyl)-5-methylthieno[2,3-d]pyrimidin-4(3H)-one

Product 1

HCID 59842858N-(2,4-difluorophenyl)-2-(6-(4-(2-fluorophenyl)piperazine-1-carbonyl)-5-methyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)acetamide

Sources & evidence

ORD record
ord-43e91cf7d5e5426f9511ed45a87e8572
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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