Toluene → methyl 5-morpholinonicotinate
Reaction equation
[CH2:12]1[CH2:13][O:14][CH2:15][CH2:16][NH:17]1.[CH3:1][O:2][C:3]([c:4]1[cH:5][n:6][cH:7][c:8]([Br:10])[cH:9]1)=[O:11].[CH3:64][c:65]1[cH:66][cH:67][cH:68][cH:69][cH:70]1.[CH3:71][CH2:72][O:73][CH2:74][CH3:75].[O:114]=[C:115]([CH:116]=[CH:117][c:118]1[cH:119][cH:120][cH:121][cH:122][cH:123]1)[CH:124]=[CH:125][c:126]1[cH:127][cH:128][cH:129][cH:130][cH:131]1.[O:78]=[C:79]([CH:80]=[CH:81][c:82]1[cH:83][cH:84][cH:85][cH:86][cH:87]1)[CH:88]=[CH:89][c:90]1[cH:91][cH:92][cH:93][cH:94][cH:95]1.[O:96]=[C:97]([CH:98]=[CH:99][c:100]1[cH:101][cH:102][cH:103][cH:104][cH:105]1)[CH:106]=[CH:107][c:108]1[cH:109][cH:110][cH:111][cH:112][cH:113]1.[Pd:76].[Pd:77].[cH:18]1[cH:19][cH:20][c:21]([P:22]([c:23]2[cH:24][cH:25][c:26]3[c:27]([cH:28][cH:29][cH:30][cH:31]3)[c:32]2-[c:33]2[c:34]3[c:35]([cH:36][cH:37][cH:38][cH:39]3)[cH:40][cH:41][c:42]2[P:43]([c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)[c:50]2[cH:51][cH:52][cH:53][cH:54][cH:55]2)[c:56]2[cH:57][cH:58][cH:59][cH:60][cH:61]2)[cH:62][cH:63]1>>[CH3:1][O:2][C:3]([c:4]1[cH:5][n:6][cH:7][c:8]([N:17]2[CH2:12][CH2:13][O:14][CH2:15][CH2:16]2)[cH:9]1)=[O:11]Participants
8
Sources & evidence
- ORD record
- ord-d32d1436c27b470e916c2731b3f677e7
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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