1-[(3,5-Difluorophenyl)methyl]piperidin-4-amine → N-(1-(3,5-Difluorobenzyl)piperidin-4-yl)-6-chloro-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine

HRID 1118646Notes

Reaction equation

HRID 1118646 reaction equation
[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[s:8][c:9]([Cl:18])[c:10]2-[c:11]1[cH:12][cH:13][c:14]([F:17])[cH:15][cH:16]1.[F:19][c:20]1[cH:21][c:22]([CH2:23][N:24]2[CH2:25][CH2:26][CH:27]([NH2:30])[CH2:28][CH2:29]2)[cH:31][c:32]([F:34])[cH:33]1>>[c:2]1([NH:30][CH:27]2[CH2:26][CH2:25][N:24]([CH2:23][c:22]3[cH:21][c:20]([F:19])[cH:33][c:32]([F:34])[cH:31]3)[CH2:29][CH2:28]2)[c:3]2[c:4]([n:5][cH:6][n:7]1)[s:8][c:9]([Cl:18])[c:10]2-[c:11]1[cH:12][cH:13][c:14]([F:17])[cH:15][cH:16]1

Participants

3

Reactant 2

HCID 221824001-[(3,5-Difluorophenyl)methyl]piperidin-4-amineHCID 579331454,6-Dichloro-5-(4-fluorophenyl)thieno[2,3-d]pyrimidine

Product 1

HCID 11670347N-(1-(3,5-Difluorobenzyl)piperidin-4-yl)-6-chloro-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine

Sources & evidence

ORD record
ord-ab2e7030145b42ffad4e5c1517c0aa2c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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