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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1118772Generated: November 1, 2026

Citric Acid → 2-[1-(2-bromo-6-chlorophenyl)pyrazolo[5,4-d]pyrimidin-4-yl]oxy-N-(5-methylpyrazin-2-yl)-3-[1-tri(propan-2-yl)silyloxypropan-2-yloxy]propanamide

https://huagongshe.com/reaction/1118772

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCitric AcidHCID 311—
ReactantSodium ionHCID 923—
ReactantTetrahydrofuranHCID 8028—
ReactantEthyl AcetateHCID 8857—
ReactantHydrideHCID 166653—
Reactant1-(2-bromo-6-chlorophenyl)-4-chloro-1H-pyrazolo[3,4-d]pyrimidineHCID 57438680—
Reactant2-hydroxy-N-(5-methylpyrazin-2-yl)-3-[1-tri(propan-2-yl)silyloxypropan-2-yloxy]propanamideHCID 66813286—
Product2-[1-(2-bromo-6-chlorophenyl)pyrazolo[5,4-d]pyrimidin-4-yl]oxy-N-(5-methylpyrazin-2-yl)-3-[1-tri(propan-2-yl)silyloxypropan-2-yloxy]propanamideHCID 76550542—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (7/10)
ORD IDord-8f7de1a47a9c40b4b4bb0a2258ca3e71
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (7/10)