Methyl Ethyl Ketone → 4'-bromo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-5,6-dihydro-2H-spiro[benzofuro[6,5-b]furan-3,3'-indolin]-2'-one

HRID 1119983Notes

Reaction equation

HRID 1119983 reaction equation
[Br:1][c:2]1[c:3]2[c:4]([cH:5][cH:6][cH:7]1)[NH:8][C:9](=[O:22])[C:10]21[CH2:11][O:12][c:13]2[c:14]1[cH:15][c:16]1[c:17]([cH:21]2)[O:18][CH2:19][CH2:20]1.[Br:29][CH2:30][c:31]1[o:32][c:33]([C:36]([F:37])([F:38])[F:39])[cH:34][cH:35]1.[C:23](=[O:24])([O-:25])[O-:26].[CH3:40][C:41](=[O:42])[CH2:43][CH3:44].[Cs+:27].[Cs+:28]>>[Br:1][c:2]1[c:3]2[c:4]([cH:5][cH:6][cH:7]1)[N:8]([CH2:30][c:31]1[o:32][c:33]([C:36]([F:37])([F:38])[F:39])[cH:34][cH:35]1)[C:9](=[O:22])[C:10]21[CH2:11][O:12][c:13]2[c:14]1[cH:15][c:16]1[c:17]([cH:21]2)[O:18][CH2:19][CH2:20]1

Participants

6

Reactant 5

HCID 6569Methyl Ethyl KetoneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 27946052-(Bromomethyl)-5-(trifluoromethyl)furanHCID 592634884'-bromo-5,6-dihydro-2H-spiro[benzofuro[6,5-b]furan-3,3'-indolin]-2'-one

Product 1

HCID 592634504'-bromo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-5,6-dihydro-2H-spiro[benzofuro[6,5-b]furan-3,3'-indolin]-2'-one

Sources & evidence

ORD record
ord-3906d7b7e4f94a97be5498d62e5b9701
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…