6-(chloromethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one → Benzyl 4-[4-(2,2-difluoro-3-phenoxypropoxy)phenyl]-3-[4-(3-methoxypropyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]piperidine-1-carboxylate

HRID 1120560Notes

Reaction equation

HRID 1120560 reaction equation
[Cl:37][CH2:38][c:39]1[cH:40][cH:41][c:42]2[c:43]([cH:54]1)[N:44]([CH2:49][CH2:50][CH2:51][O:52][CH3:53])[C:45](=[O:48])[CH2:46][O:47]2.[F:1][C:2]([CH2:3][O:4][c:5]1[cH:6][cH:7][c:8]([CH:11]2[CH:12]([OH:27])[CH2:13][N:14]([C:17](=[O:18])[O:19][CH2:20][c:21]3[cH:22][cH:23][cH:24][cH:25][cH:26]3)[CH2:15][CH2:16]2)[cH:9][cH:10]1)([CH2:28][O:29][c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1)[F:36]>>[F:1][C:2]([CH2:3][O:4][c:5]1[cH:6][cH:7][c:8]([CH:11]2[CH:12]([O:27][CH2:38][c:39]3[cH:40][cH:41][c:42]4[c:43]([cH:54]3)[N:44]([CH2:49][CH2:50][CH2:51][O:52][CH3:53])[C:45](=[O:48])[CH2:46][O:47]4)[CH2:13][N:14]([C:17](=[O:18])[O:19][CH2:20][c:21]3[cH:22][cH:23][cH:24][cH:25][cH:26]3)[CH2:15][CH2:16]2)[cH:9][cH:10]1)([CH2:28][O:29][c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1)[F:36]

Participants

3

Reactant 2

HCID 468352236-(chloromethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-oneHCID 68500743HCID 68500743, compound

Product 1

HCID 68505370Benzyl 4-[4-(2,2-difluoro-3-phenoxypropoxy)phenyl]-3-[4-(3-methoxypropyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-fb792252d81942a1a606fa2ebf887228
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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