Isobutylamine → 2,5-Difluoro-N-{2-fluoro-5-[5-{2-[(2-methylpropyl)amino]-4-pyrimidinyl}-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

HRID 1120641Notes

Reaction equation

HRID 1120641 reaction equation
[CH2:38]([CH:39]([CH3:40])[CH3:41])[NH2:42].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:19]3[cH:20][cH:21][c:22]([F:37])[c:23]([NH:25][S:26](=[O:27])(=[O:28])[c:29]4[c:30]([F:36])[cH:31][cH:32][c:33]([F:35])[cH:34]4)[cH:24]3)[n:10][c:11]([CH:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)[s:12]2)[n:7]1>>[c:2]1([NH:42][CH2:38][CH:39]([CH3:40])[CH3:41])[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:19]3[cH:20][cH:21][c:22]([F:37])[c:23]([NH:25][S:26](=[O:27])(=[O:28])[c:29]4[c:30]([F:36])[cH:31][cH:32][c:33]([F:35])[cH:34]4)[cH:24]3)[n:10][c:11]([CH:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)[s:12]2)[n:7]1

Participants

3

Reactant 2

HCID 6558IsobutylamineHCID 57989666N-{5-[5-(2-Chloro-4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

Product 1

HCID 579896552,5-Difluoro-N-{2-fluoro-5-[5-{2-[(2-methylpropyl)amino]-4-pyrimidinyl}-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Sources & evidence

ORD record
ord-5511ab65ad0a498e884d66737b2c88ec
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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