Water → 3-(4,5-Difluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)quinoline
Reaction equation
[CH2:10]([Cl:11])[Cl:12].[CH2:1]([N:2]([S:3]([F:4])([F:5])[F:7])[CH2:6][CH3:8])[CH3:9].[F:13][c:14]1[c:15]2[c:20]([cH:21][cH:22][cH:23]1)[C:19]([c:24]1[cH:25][n:26][c:27]3[cH:28][cH:29][cH:30][cH:31][c:32]3[cH:33]1)=[N:18][C:17]([CH3:34])([CH3:35])[CH:16]2[OH:36].[OH2:37]>>[F:7][CH:16]1[c:15]2[c:14]([F:13])[cH:23][cH:22][cH:21][c:20]2[C:19]([c:24]2[cH:25][n:26][c:27]3[cH:28][cH:29][cH:30][cH:31][c:32]3[cH:33]2)=[N:18][C:17]1([CH3:34])[CH3:35]Participants
5
Sources & evidence
- ORD record
- ord-ba6848110be64a288cc379d009a78cb8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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