N-[3-(3-{2-[{3-[(4-Amino-2-fluorophenyl)oxy]propyl}(methyl)amino]-4-pyrimidinyl}pyrazolo[1,5-a]pyridin-2-yl)phenyl]-2,6-difluorobenzamide → 3-Fluoro-4-[2-(1-piperidinyl)ethoxy]phenylamine

HRID 1121042Notes

Reaction equation

HRID 1121042 reaction equation
[F:47][c:48]1[c:49]([O:57][CH2:58][CH2:59][N:60]2[CH2:61][CH2:62][CH2:63][CH2:64][CH2:65]2)[cH:50][cH:51][c:52]([N+:54]([O-:55])=[O:56])[cH:53]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]([O:6][CH2:7][CH2:8][CH2:9][N:10]([CH3:11])[c:12]2[n:13][c:14](-[c:15]3[c:16](-[c:17]4[cH:18][c:19]([NH:20][C:21](=[O:22])[c:23]5[c:24]([F:25])[cH:26][cH:27][cH:28][c:29]5[F:30])[cH:31][cH:32][cH:33]4)[n:34][n:35]4[cH:36][cH:37][cH:38][cH:39][c:40]34)[cH:41][cH:42][n:43]2)[c:44]([F:45])[cH:46]1>>[F:47][c:48]1[c:49]([O:57][CH2:58][CH2:59][N:60]2[CH2:61][CH2:62][CH2:63][CH2:64][CH2:65]2)[cH:50][cH:51][c:52]([NH2:54])[cH:53]1

Participants

3

Reactant 2

HCID 59513855N-[3-(3-{2-[{3-[(4-Amino-2-fluorophenyl)oxy]propyl}(methyl)amino]-4-pyrimidinyl}pyrazolo[1,5-a]pyridin-2-yl)phenyl]-2,6-difluorobenzamideHCID 595138651-[2-(2-Fluoro-4-nitrophenoxy)ethyl]piperidine

Product 1

HCID 196272493-Fluoro-4-[2-(1-piperidinyl)ethoxy]phenylamine

Sources & evidence

ORD record
ord-b3aa80bec68a41ada4f2ccb8377a53ac
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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