Methanol → 3'-Amino-6-chloro-N-[3-(trifluoromethyl)phenyl]biphenyl-3-carboxamide

HRID 1121718Notes

Reaction equation

HRID 1121718 reaction equation
[CH3:37][OH:38].[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:17](=[O:18])[NH:19][c:20]2[cH:21][c:22]([C:26]([F:27])([F:28])[F:29])[cH:23][cH:24][cH:25]2)[cH:6][c:7]1-[c:8]1[cH:9][c:10]([N+:14]([O-:15])=[O:16])[cH:11][cH:12][cH:13]1.[NH2:30][c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1.[OH-:39].[OH-:41].[Pd+2:40]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:17](=[O:18])[NH:19][c:20]2[cH:21][c:22]([C:26]([F:27])([F:28])[F:29])[cH:23][cH:24][cH:25]2)[cH:6][c:7]1-[c:8]1[cH:9][c:10]([NH2:14])[cH:11][cH:12][cH:13]1

Participants

6

Reactant 5

HCID 887MethanolHCID 961Hydroxide2×HCID 6115AnilineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 692724446-Chloro-3'-nitro-N-[3-(trifluoromethyl)phenyl]biphenyl-3-carboxamide

Product 1

HCID 692744463'-Amino-6-chloro-N-[3-(trifluoromethyl)phenyl]biphenyl-3-carboxamide

Sources & evidence

ORD record
ord-e85035f184fa42dd9e06e78e748a6e4f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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