反应详情

温度

65 °C

The mixture of Isomer A of 4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepane (3 mg), paraformaldehyde (3 mg) and formic acid (2.2 mg) in chloroform (0.1 mL) was stirred at 65° C. for overnight. After cooling down, the mixture was concentrated under vacuum and filtered through anion exchange cartridge to get rid of formic acid. The crude product was purified by prep TLC with 10% methanol/89% dichloromethane/1% NH4OH to give the product as a clear sticky oil (2 mg, 67% yield).

1. temperatureAfter cooling down
2. concentrationthe mixture was concentrated under vacuum
3. filtrationfiltered through anion exchange cartridge
4. customto get rid of formic acid
5. customThe crude product was purified by prep TLC with 10% methanol/89% dichloromethane/1% NH4OH