1-(Oxan-4-yl)piperazine → 2-[[4-amino-3-chloro-5-(trifluoromethyl)phenyl]methyl]-1-[4-(oxan-4-yl)piperazin-1-yl]-4-[4-(2-oxo-1H-imidazo[4,5-c]quinolin-3-yl)piperidin-1-yl]butane-1,4-dione
Reaction equation
[NH2:1][c:2]1[c:3]([Cl:40])[cH:4][c:5]([CH2:6][CH:7]([C:8](=[O:9])[OH:10])[CH2:11][C:12]([N:13]2[CH2:14][CH2:15][CH:16]([n:19]3[c:20](=[O:32])[nH:21][c:22]4[c:23]3[cH:24][n:25][c:26]3[cH:27][cH:28][cH:29][cH:30][c:31]43)[CH2:17][CH2:18]2)=[O:33])[cH:34][c:35]1[C:36]([F:37])([F:38])[F:39].[O:41]1[CH2:42][CH2:43][CH:44]([N:47]2[CH2:48][CH2:49][NH:50][CH2:51][CH2:52]2)[CH2:45][CH2:46]1>>[NH2:1][c:2]1[c:3]([Cl:40])[cH:4][c:5]([CH2:6][CH:7]([C:8](=[O:10])[N:50]2[CH2:49][CH2:48][N:47]([CH:44]3[CH2:43][CH2:42][O:41][CH2:46][CH2:45]3)[CH2:52][CH2:51]2)[CH2:11][C:12]([N:13]2[CH2:14][CH2:15][CH:16]([n:19]3[c:20](=[O:32])[nH:21][c:22]4[c:23]3[cH:24][n:25][c:26]3[cH:27][cH:28][cH:29][cH:30][c:31]43)[CH2:17][CH2:18]2)=[O:33])[cH:34][c:35]1[C:36]([F:37])([F:38])[F:39]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-da798504e4b9464fa1ddfd0c11e00389
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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