(2-Aminopyrimidin-5-yl)boronic acid → [5-(2-Amino-pyrimidin-5-yl)-3-methyl-2-(4-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

HRID 1121945Notes

Reaction equation

HRID 1121945 reaction equation
[I:1][c:2]1[c:3]([C:18](=[O:19])[N:20]2[CH2:21][CH2:22][CH:23]([N:26]3[CH2:27][CH2:28][CH2:29][CH2:30]3)[CH2:24][CH2:25]2)[n:4]([CH3:17])[c:5](-[c:7]2[cH:8][cH:9][c:10]([C:13]([F:14])([F:15])[F:16])[cH:11][cH:12]2)[n:6]1.[NH2:31][c:32]1[n:33][cH:34][c:35]([B:38]([OH:39])[OH:40])[cH:36][n:37]1>>[c:2]1(-[c:35]2[cH:34][n:33][c:32]([NH2:31])[n:37][cH:36]2)[c:3]([C:18](=[O:19])[N:20]2[CH2:21][CH2:22][CH:23]([N:26]3[CH2:27][CH2:28][CH2:29][CH2:30]3)[CH2:24][CH2:25]2)[n:4]([CH3:17])[c:5](-[c:7]2[cH:8][cH:9][c:10]([C:13]([F:14])([F:15])[F:16])[cH:11][cH:12]2)[n:6]1

Participants

3

Reactant 2

HCID 17750211(2-Aminopyrimidin-5-yl)boronic acidHCID 57541088[5-iodo-3-methyl-2-(4-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

Product 1

HCID 57541126[5-(2-Amino-pyrimidin-5-yl)-3-methyl-2-(4-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

Sources & evidence

ORD record
ord-e9425e62657f434395236e8ca4e9b9a8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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