6-(chloromethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one → tert-Butyl 4-{4-[3-(2,6-difluorophenoxy)propoxy]phenyl}-3-[4-(3-methoxypropyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]piperidine-1-carboxylate

HRID 1122490Notes

Reaction equation

HRID 1122490 reaction equation
[Cl:34][CH2:35][c:36]1[cH:37][cH:38][c:39]2[c:40]([cH:51]1)[N:41]([CH2:46][CH2:47][CH2:48][O:49][CH3:50])[C:42](=[O:45])[CH2:43][O:44]2.[F:1][c:2]1[c:3]([O:4][CH2:5][CH2:6][CH2:7][O:8][c:9]2[cH:10][cH:11][c:12]([CH:15]3[CH:16]([OH:28])[CH2:17][N:18]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:19][CH2:20]3)[cH:13][cH:14]2)[c:29]([F:33])[cH:30][cH:31][cH:32]1>>[F:1][c:2]1[c:3]([O:4][CH2:5][CH2:6][CH2:7][O:8][c:9]2[cH:10][cH:11][c:12]([CH:15]3[CH:16]([O:28][CH2:35][c:36]4[cH:37][cH:38][c:39]5[c:40]([cH:51]4)[N:41]([CH2:46][CH2:47][CH2:48][O:49][CH3:50])[C:42](=[O:45])[CH2:43][O:44]5)[CH2:17][N:18]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:19][CH2:20]3)[cH:13][cH:14]2)[c:29]([F:33])[cH:30][cH:31][cH:32]1

Participants

3

Reactant 2

HCID 468352236-(chloromethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-oneHCID 68503496Tert-butyl 4-{4-[3-(2,6-difluorophenoxy)propoxy]phenyl}-3-hydroxypiperidine-1-carboxylate

Product 1

HCID 68503153tert-Butyl 4-{4-[3-(2,6-difluorophenoxy)propoxy]phenyl}-3-[4-(3-methoxypropyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-b1689d0cf5eb497c960d2a84d729f012
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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