2-(4-Iodophenyl)propan-2-ol → 2-[4-(1-Hydroxy-1-methyl-ethyl)-phenyl]-8-(2-trifluoromethyl-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one
Reaction equation
[F:1][C:2]([c:3]1[c:4]([S:9](=[O:10])(=[O:11])[N:12]2[CH2:13][CH2:14][C:15]3([CH2:16][CH2:17][NH:18][C:19]3=[O:20])[CH2:21][CH2:22]2)[cH:5][cH:6][cH:7][cH:8]1)([F:23])[F:24].[F:25][C:26]([F:27])([F:28])[CH:29]([c:30]1[cH:31][cH:32][c:33]([N:34]2[CH2:35][CH2:36][C:37]3([CH2:38][CH2:39][N:40]([S:41]([c:42]4[cH:43][cH:44][cH:45][cH:46][c:47]4[C:48]([F:49])([F:50])[F:51])(=[O:52])=[O:53])[CH2:54][CH2:55]3)[C:56]2=[O:57])[cH:58][cH:59]1)[OH:60].[I:61][c:62]1[cH:63][cH:64][c:65]([C:68]([CH3:69])([CH3:70])[OH:71])[cH:66][cH:67]1>>[F:1][C:2]([c:3]1[c:4]([S:9](=[O:10])(=[O:11])[N:12]2[CH2:13][CH2:14][C:15]3([CH2:16][CH2:17][N:18]([c:62]4[cH:63][cH:64][c:65]([C:68]([CH3:69])([CH3:70])[OH:71])[cH:66][cH:67]4)[C:19]3=[O:20])[CH2:21][CH2:22]2)[cH:5][cH:6][cH:7][cH:8]1)([F:23])[F:24]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-bcf650a0682a4c478f7a3a9bf1fe32ac
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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