4-[(1-Methyl-1H-pyrazol-3-yl)amino]quinazolin-6-ol → 5-chloro-N-methyl-6-({4-[(1-methyl-1H-pyrazol-3-yl)amino]quinazolin-6-yl}oxy)-N-(2-pyrrolidin-1-ylethyl)nicotinamide

HRID 1122822Notes

Reaction equation

HRID 1122822 reaction equation
[CH3:1][n:2]1[n:3][c:4]([NH:7][c:8]2[n:9][cH:10][n:11][c:12]3[cH:13][cH:14][c:15]([OH:18])[cH:16][c:17]23)[cH:5][cH:6]1.[Cl:19][c:20]1[c:21]([Cl:37])[n:22][cH:23][c:24]([C:25](=[O:26])[N:27]([CH2:28][CH2:29][N:30]2[CH2:31][CH2:32][CH2:33][CH2:34]2)[CH3:35])[cH:36]1>>[CH3:1][n:2]1[n:3][c:4]([NH:7][c:8]2[n:9][cH:10][n:11][c:12]3[cH:13][cH:14][c:15]([O:18][c:21]4[c:20]([Cl:19])[cH:36][c:24]([C:25](=[O:26])[N:27]([CH2:28][CH2:29][N:30]5[CH2:31][CH2:32][CH2:33][CH2:34]5)[CH3:35])[cH:23][n:22]4)[cH:16][c:17]23)[cH:5][cH:6]1

Participants

3

Reactant 2

HCID 231603824-[(1-Methyl-1H-pyrazol-3-yl)amino]quinazolin-6-olHCID 551618625,6-dichloro-N-methyl-N-(2-pyrrolidin-1-ylethyl)nicotinamide

Product 1

HCID 426110345-chloro-N-methyl-6-({4-[(1-methyl-1H-pyrazol-3-yl)amino]quinazolin-6-yl}oxy)-N-(2-pyrrolidin-1-ylethyl)nicotinamide

Sources & evidence

ORD record
ord-b653371484724c539ef918962e4aabdc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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