Ethylene Glycol → Emedastine EP Impurity E

HRID 1122933Notes

Reaction equation

HRID 1122933 reaction equation
[CH2:6]([O:7][C:8](=[O:9])[N:11]1[CH2:12][CH2:13][N:14]([c:18]2[n:19][c:20]3[c:21]([n:22]2[CH2:23][CH2:24][O:25][CH2:26][CH3:27])[cH:28][cH:29][cH:30][cH:31]3)[CH2:15][CH2:16][CH2:17]1)[CH3:10].[CH3:1][OH:2].[Cl:3][CH2:4][Cl:5].[K+:36].[NH2:33][NH2:34].[OH-:35].[OH2:32].[OH2:41].[OH:37][CH2:38][CH2:39][OH:40]>>[NH:11]1[CH2:12][CH2:13][N:14]([c:18]2[n:19][c:20]3[c:21]([n:22]2[CH2:23][CH2:24][O:25][CH2:26][CH3:27])[cH:28][cH:29][cH:30][cH:31]3)[CH2:15][CH2:16][CH2:17]1

Participants

9

Reactant 8

HCID 174Ethylene GlycolHCID 813Potassium CationHCID 887MethanolHCID 961HydroxideHCID 962Water2×HCID 6344DichloromethaneHCID 9321HydrazineHCID 143561191-ethoxycarbonyl-4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane

Product 1

HCID 9984168Emedastine EP Impurity E

Sources & evidence

ORD record
ord-2048de99305749639217f4d8bf427cd2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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