4-(Trifluoromethyl)phenylboronic acid → [2,6-Dimethyl-4-[4-(trifluoromethyl)phenyl]phenyl]-[4-[2-(hydroxymethyl)pyrrolidin-1-yl]piperidin-1-yl]methanone
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([CH3:24])[c:5]([C:9](=[O:10])[N:11]2[CH2:12][CH2:13][CH:14]([N:17]3[CH:18]([CH2:22][OH:23])[CH2:19][CH2:20][CH2:21]3)[CH2:15][CH2:16]2)[c:6]([CH3:8])[cH:7]1.[F:25][C:26]([c:27]1[cH:28][cH:29][c:30]([B:33]([OH:34])[OH:35])[cH:31][cH:32]1)([F:36])[F:37]>>[c:2]1(-[c:30]2[cH:29][cH:28][c:27]([C:26]([F:25])([F:36])[F:37])[cH:32][cH:31]2)[cH:3][c:4]([CH3:24])[c:5]([C:9](=[O:10])[N:11]2[CH2:12][CH2:13][CH:14]([N:17]3[CH:18]([CH2:22][OH:23])[CH2:19][CH2:20][CH2:21]3)[CH2:15][CH2:16]2)[c:6]([CH3:8])[cH:7]1Participants
3
Sources & evidence
- ORD record
- ord-2908f54544e14404bd10e324024c0971
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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