Methyl 5-aminobenzofuran-2-carboxylate → 5-fluoro-N4-(3-hydroxyphenyl)-N2-(2-methoxycarbonylbenzofuran-5-yl)-2,4-pyrimidinediamine

HRID 1123408Notes

Reaction equation

HRID 1123408 reaction equation
[CH3:17][O:18][C:19](=[O:20])[c:21]1[o:22][c:23]2[c:24]([cH:25]1)[cH:26][c:27]([NH2:30])[cH:28][cH:29]2.[Cl:1][c:2]1[n:3][cH:4][c:5]([F:16])[c:6]([NH:8][c:9]2[cH:10][c:11]([OH:15])[cH:12][cH:13][cH:14]2)[n:7]1>>[c:2]1([NH:30][c:27]2[cH:26][c:24]3[c:23]([o:22][c:21]([C:19]([O:18][CH3:17])=[O:20])[cH:25]3)[cH:29][cH:28]2)[n:3][cH:4][c:5]([F:16])[c:6]([NH:8][c:9]2[cH:10][c:11]([OH:15])[cH:12][cH:13][cH:14]2)[n:7]1

Participants

3

Reactant 2

HCID 10845388Methyl 5-aminobenzofuran-2-carboxylateHCID 220604512-chloro-5-fluoro-N-(3-hydroxyphenyl)-4-pyrimidineamine

Product 1

HCID 220602755-fluoro-N4-(3-hydroxyphenyl)-N2-(2-methoxycarbonylbenzofuran-5-yl)-2,4-pyrimidinediamine

Sources & evidence

ORD record
ord-9b33c1172b5e4c61a152c043e1b7f4c0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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