Acetate → N-(3-(4-(4-Amino-2-fluorophenoxy)pyrrolo[2,1-f][1,2,4]triazin-5-yl)phenyl)acetamide

HRID 1123428Notes

Reaction equation

HRID 1123428 reaction equation
[BH:20]([OH:21])[OH:22].[C:23]([CH3:24])(=[O:25])[NH:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1.[C:41]([O-:42])(=[O:43])[CH3:44].[C:46]([O-:47])(=[O:48])[CH3:49].[Cl:1][c:2]1[cH:3][cH:4][n:5]2[n:6][cH:7][n:8][c:9]([O:11][c:12]3[c:13]([F:19])[cH:14][c:15]([NH2:18])[cH:16][cH:17]3)[c:10]12.[K+:38].[K+:39].[K+:40].[P:33]([O-:34])([O-:35])([O-:36])=[O:37].[Pd+2:45]>>[c:2]1(-[c:31]2[cH:30][cH:29][cH:28][c:27]([NH:26][C:23]([CH3:24])=[O:25])[cH:32]2)[cH:3][cH:4][n:5]2[n:6][cH:7][n:8][c:9]([O:11][c:12]3[c:13]([F:19])[cH:14][c:15]([NH2:18])[cH:16][cH:17]3)[c:10]12

Participants

8

Reactant 7

HCID 175Acetate2×HCID 813Potassium Cation3×HCID 904AcetanilideHCID 1061PhosphateHCID 61668Boronic AcidHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 210816684-(5-Chloropyrrolo[2,1-f][1,2,4]triazin-4-yloxy)-3-fluorobenzenamine

Product 1

HCID 21081735N-(3-(4-(4-Amino-2-fluorophenoxy)pyrrolo[2,1-f][1,2,4]triazin-5-yl)phenyl)acetamide

Sources & evidence

ORD record
ord-7a169828fab143288eea3df5597a473a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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