Potassium Cation → 3-(5-Chloro-8-fluoroisoquinolin-3-yl)-5-[1-(8-methyl-8-azabicyclo [3.2.1]-oct-3-yl)-1H-pyrazol-4-yl]-pyridin-2-ylamine
Reaction equation
[C:44](=[O:45])([O-:46])[O-:47].[CH3:127][O:128][CH2:129][CH2:130][O:131][CH3:132].[Cl:16][c:17]1[c:18]2[cH:19][c:20](-[c:28]3[c:29]([NH2:43])[n:30][cH:31][c:32]([B:34]4[O:35][C:36]([CH3:37])([CH3:38])[C:39]([CH3:40])([CH3:41])[O:42]4)[cH:33]3)[n:21][cH:22][c:23]2[c:24]([F:27])[cH:25][cH:26]1.[I:1][c:2]1[cH:3][n:4][n:5]([CH:7]2[CH2:8][CH:9]3[CH2:10][CH2:11][CH:12]([CH2:13]2)[N:14]3[CH3:15])[cH:6]1.[K+:48].[K+:49].[OH2:133].[cH:50]1[cH:51][cH:52][c:53]([P:54]([Pd:55]([P:56]([c:57]2[cH:58][cH:59][cH:60][cH:61][cH:62]2)([c:63]2[cH:64][cH:65][cH:66][cH:67][cH:68]2)[c:69]2[cH:70][cH:71][cH:72][cH:73][cH:74]2)([P:75]([c:76]2[cH:77][cH:78][cH:79][cH:80][cH:81]2)([c:82]2[cH:83][cH:84][cH:85][cH:86][cH:87]2)[c:88]2[cH:89][cH:90][cH:91][cH:92][cH:93]2)[P:94]([c:95]2[cH:96][cH:97][cH:98][cH:99][cH:100]2)([c:101]2[cH:102][cH:103][cH:104][cH:105][cH:106]2)[c:107]2[cH:108][cH:109][cH:110][cH:111][cH:112]2)([c:113]2[cH:114][cH:115][cH:116][cH:117][cH:118]2)[c:119]2[cH:120][cH:121][cH:122][cH:123][cH:124]2)[cH:125][cH:126]1>>[c:2]1(-[c:32]2[cH:31][n:30][c:29]([NH2:43])[c:28](-[c:20]3[cH:19][c:18]4[c:17]([Cl:16])[cH:26][cH:25][c:24]([F:27])[c:23]4[cH:22][n:21]3)[cH:33]2)[cH:3][n:4][n:5]([CH:7]2[CH2:8][CH:9]3[CH2:10][CH2:11][CH:12]([CH2:13]2)[N:14]3[CH3:15])[cH:6]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-7a1bea2a9bcc47cb9b18da7dc91f1f03
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
Loading…