Toluene → Tert-butyl 4-(4-(8-ethyl-4-methyl-7-oxo-6-(thiazol-2-yl)-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl)piperazine-1-carboxylate

HRID 1123678Notes

Reaction equation

HRID 1123678 reaction equation
[C:21]([CH3:22])([CH3:23])([CH3:24])[O:25][C:26](=[O:27])[N:28]1[CH2:29][CH2:30][N:31]([c:34]2[cH:35][cH:36][c:37]([I:40])[cH:38][cH:39]2)[CH2:32][CH2:33]1.[CH3:41][c:42]1[cH:43][cH:44][cH:45][cH:46][cH:47]1.[NH2:1][c:2]1[n:3][c:4]([CH3:20])[c:5]2[c:6]([n:7]1)[n:8]([CH2:18][CH3:19])[c:9](=[O:17])[c:10](-[c:12]1[s:13][cH:14][cH:15][n:16]1)[cH:11]2>>[NH:1]([c:2]1[n:3][c:4]([CH3:20])[c:5]2[c:6]([n:7]1)[n:8]([CH2:18][CH3:19])[c:9](=[O:17])[c:10](-[c:12]1[s:13][cH:14][cH:15][n:16]1)[cH:11]2)[c:37]1[cH:36][cH:35][c:34]([N:31]2[CH2:30][CH2:29][N:28]([C:26]([O:25][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:27])[CH2:33][CH2:32]2)[cH:39][cH:38]1

Participants

4

Reactant 3

HCID 1140TolueneHCID 2795511Tert-butyl 4-(4-iodophenyl)piperazine-1-carboxylateHCID 161233812-amino-8-ethyl-4-methyl-6-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7(8H)-one

Product 1

HCID 57606982Tert-butyl 4-(4-(8-ethyl-4-methyl-7-oxo-6-(thiazol-2-yl)-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-e064bb96bf544a8db9f6bd6794372bd4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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