Isobutylamine → N-[2-Chloro-3-(2-(1,1-dimethylethyl)-5-{2-[(2-methylpropyl)amino]-4-pyrimidinyl}-1,3-thiazol-4-yl)phenyl]-2,6-difluorobenzenesulfonamide

HRID 1124342Notes

Reaction equation

HRID 1124342 reaction equation
[CH2:36]([CH:37]([CH3:38])[CH3:39])[NH2:40].[Cl:1][c:2]1[c:3]([NH:24][S:25](=[O:26])(=[O:27])[c:28]2[c:29]([F:35])[cH:30][cH:31][cH:32][c:33]2[F:34])[cH:4][cH:5][cH:6][c:7]1-[c:8]1[n:9][c:10]([C:20]([CH3:21])([CH3:22])[CH3:23])[s:11][c:12]1-[c:13]1[n:14][c:15]([Cl:19])[n:16][cH:17][cH:18]1>>[Cl:1][c:2]1[c:3]([NH:24][S:25](=[O:26])(=[O:27])[c:28]2[c:29]([F:35])[cH:30][cH:31][cH:32][c:33]2[F:34])[cH:4][cH:5][cH:6][c:7]1-[c:8]1[n:9][c:10]([C:20]([CH3:21])([CH3:22])[CH3:23])[s:11][c:12]1-[c:13]1[n:14][c:15]([NH:40][CH2:36][CH:37]([CH3:38])[CH3:39])[n:16][cH:17][cH:18]1

Participants

3

Reactant 2

HCID 6558IsobutylamineHCID 57989879N-{2-Chloro-3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

Product 1

HCID 57990060N-[2-Chloro-3-(2-(1,1-dimethylethyl)-5-{2-[(2-methylpropyl)amino]-4-pyrimidinyl}-1,3-thiazol-4-yl)phenyl]-2,6-difluorobenzenesulfonamide

Sources & evidence

ORD record
ord-6f59c638bd174b72900a6f733300563c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…