4-(2,3-Difluoro-phenyl)-1,3-dihydro-indol-2-one → 2-[[4-(2,3-difluorophenyl)-2-oxo-1H-indol-3-ylidene]methyl]-5-(2-hydroxy-3-morpholin-4-ylpropyl)-3-methyl-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4-one

HRID 1124593Notes

Reaction equation

HRID 1124593 reaction equation
[F:24][c:25]1[c:26](-[c:32]2[c:33]3[c:37]([cH:38][cH:39][cH:40]2)[NH:36][C:35](=[O:41])[CH2:34]3)[cH:27][cH:28][cH:29][c:30]1[F:31].[OH:1][CH:2]([CH2:3][N:4]1[C:5](=[O:16])[c:6]2[c:7]([nH:10][c:11]([CH:14]=[O:15])[c:12]2[CH3:13])[CH2:8][CH2:9]1)[CH2:17][N:18]1[CH2:19][CH2:20][O:21][CH2:22][CH2:23]1>>[OH:1][CH:2]([CH2:3][N:4]1[C:5](=[O:16])[c:6]2[c:7]([nH:10][c:11]([CH:14]=[C:34]3[c:33]4[c:32](-[c:26]5[c:25]([F:24])[c:30]([F:31])[cH:29][cH:28][cH:27]5)[cH:40][cH:39][cH:38][c:37]4[NH:36][C:35]3=[O:41])[c:12]2[CH3:13])[CH2:8][CH2:9]1)[CH2:17][N:18]1[CH2:19][CH2:20][O:21][CH2:22][CH2:23]1

Participants

3

Reactant 2

HCID 225619714-(2,3-Difluoro-phenyl)-1,3-dihydro-indol-2-oneHCID 593759885-(2-hydroxy-3-morpholin-4-ylpropyl)-3-methyl-4-oxo-6,7-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carbaldehyde

Product 1

HCID 675319912-[[4-(2,3-difluorophenyl)-2-oxo-1H-indol-3-ylidene]methyl]-5-(2-hydroxy-3-morpholin-4-ylpropyl)-3-methyl-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4-one

Sources & evidence

ORD record
ord-3e1ba82e653941d884fbde40fc3045cd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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