2-(7-Amino-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-N-methyl-acetamide → 2-{7-[5-Fluoro-4-(2-methoxy-4-morpholin-4-yl-phenylamino)-pyrimidin-2-ylamino]-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl}-N-methyl-acetamide

HRID 1124965Notes

Reaction equation

HRID 1124965 reaction equation
[Cl:20][c:21]1[n:22][cH:23][c:24]([F:42])[c:25]([NH:27][c:28]2[c:29]([O:40][CH3:41])[cH:30][c:31]([N:34]3[CH2:35][CH2:36][O:37][CH2:38][CH2:39]3)[cH:32][cH:33]2)[n:26]1.[NH2:1][c:2]1[cH:3][c:4]2[c:5]([cH:16][c:17]1[O:18][CH3:19])[CH2:6][CH2:7][N:8]([CH2:11][C:12](=[O:13])[NH:14][CH3:15])[CH2:9][CH2:10]2>>[NH:1]([c:2]1[cH:3][c:4]2[c:5]([cH:16][c:17]1[O:18][CH3:19])[CH2:6][CH2:7][N:8]([CH2:11][C:12](=[O:13])[NH:14][CH3:15])[CH2:9][CH2:10]2)[c:21]1[n:22][cH:23][c:24]([F:42])[c:25]([NH:27][c:28]2[c:29]([O:40][CH3:41])[cH:30][c:31]([N:34]3[CH2:35][CH2:36][O:37][CH2:38][CH2:39]3)[cH:32][cH:33]2)[n:26]1

Participants

3

Reactant 2

HCID 672635732-(7-Amino-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-N-methyl-acetamideHCID 86633934(2-Chloro-5-fluoro-pyrimidin-4-yl)-(2-methoxy-4-morpholin-4-yl-phenyl)-amine

Product 1

HCID 668306372-{7-[5-Fluoro-4-(2-methoxy-4-morpholin-4-yl-phenylamino)-pyrimidin-2-ylamino]-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl}-N-methyl-acetamide

Sources & evidence

ORD record
ord-ea43a8d80da54e5cb5141332afa08e7a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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