(2,4-Dimethoxypyrimidin-5-yl)boronic acid → 2-(2,4-Dimethoxypyrimidin-5-yl)-6-((4-(methylsulfonyl)piperidin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidine

HRID 112585Notes

Reaction equation

HRID 112585 reaction equation
[CH3:28][O:29][c:30]1[n:31][cH:32][c:33]([B:38]([OH:39])[OH:40])[c:34]([O:36][CH3:37])[n:35]1.[Cl:1][c:2]1[n:3][c:4]([N:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH2:11][N:12]1[CH2:13][CH2:14][CH:15]([S:18](=[O:19])(=[O:20])[CH3:21])[CH2:16][CH2:17]1)[s:10]2>>[c:2]1(-[c:33]2[cH:32][n:31][c:30]([O:29][CH3:28])[n:35][c:34]2[O:36][CH3:37])[n:3][c:4]([N:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH2:11][N:12]1[CH2:13][CH2:14][CH:15]([S:18](=[O:19])(=[O:20])[CH3:21])[CH2:16][CH2:17]1)[s:10]2

Participants

3

Reactant 2

HCID 2736209(2,4-Dimethoxypyrimidin-5-yl)boronic acidHCID 574940442-Chloro-6-(4-methanesulfonyl-piperidin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

Product 1

HCID 582340632-(2,4-Dimethoxypyrimidin-5-yl)-6-((4-(methylsulfonyl)piperidin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidine

Sources & evidence

ORD record
ord-38f0055731e3418c9afe291a15c5b533
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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