Boronic Acid → (4-{[4-Fluoro-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamic acid tert-butyl ester
Reaction equation
[BH:1]([OH:2])[OH:3].[Br:28][c:29]1[cH:30][cH:31][c:32]([C:35]([C:36]([F:37])([F:38])[F:39])=[O:40])[cH:33][cH:34]1.[C:4](=[O:5])([O:6][C:7]([CH3:8])([CH3:9])[CH3:10])[N:11]([CH:12]1[CH2:13][CH2:14][CH:15]([NH:18][CH2:19][c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]2[F:26])[CH2:16][CH2:17]1)[CH3:27]>>[C:4](=[O:5])([O:6][C:7]([CH3:8])([CH3:9])[CH3:10])[N:11]([CH:12]1[CH2:13][CH2:14][CH:15]([NH:18][CH2:19][c:20]2[cH:21][c:22](-[c:29]3[cH:30][cH:31][c:32]([C:35]([C:36]([F:37])([F:38])[F:39])=[O:40])[cH:33][cH:34]3)[cH:23][cH:24][c:25]2[F:26])[CH2:16][CH2:17]1)[CH3:27]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-aaf45e995c6e499a96d922ec5b11f76c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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