2-Fluorobenzenesulphonyl chloride → N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2-fluorobenzenesulfonamide

HRID 1126053Notes

Reaction equation

HRID 1126053 reaction equation
[F:25][c:26]1[c:27]([S:32](=[O:33])(=[O:34])[Cl:35])[cH:28][cH:29][cH:30][cH:31]1.[NH2:1][c:2]1[c:3]([F:24])[c:4](-[c:8]2[n:9][c:10]([C:20]([CH3:21])([CH3:22])[CH3:23])[s:11][c:12]2-[c:13]2[n:14][c:15]([NH2:19])[n:16][cH:17][cH:18]2)[cH:5][cH:6][cH:7]1>>[NH:1]([c:2]1[c:3]([F:24])[c:4](-[c:8]2[n:9][c:10]([C:20]([CH3:21])([CH3:22])[CH3:23])[s:11][c:12]2-[c:13]2[n:14][c:15]([NH2:19])[n:16][cH:17][cH:18]2)[cH:5][cH:6][cH:7]1)[S:32]([c:27]1[c:26]([F:25])[cH:31][cH:30][cH:29][cH:28]1)(=[O:33])=[O:34]

Participants

3

Reactant 2

HCID 1377612-Fluorobenzenesulphonyl chlorideHCID 579897094-[4-(3-Amino-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinamine

Product 1

HCID 57989925N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2-fluorobenzenesulfonamide

Sources & evidence

ORD record
ord-7a89e05bfbd54fc3b0fbd621be672638
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…