Potassium Cation → 2-(2,2-Difluoropropyl)-N-(4-methyl-3-(5-methylpyridin-2-yl)phenyl)-1,2,3,4-tetrahydroisoquinolin-5-amine
Reaction equation
[Br:1][c:2]1[c:3]2[c:8]([cH:9][cH:10][cH:11]1)[CH2:7][N:6]([CH2:12][C:13]([CH3:14])([F:15])[F:16])[CH2:5][CH2:4]2.[CH3:17][c:18]1[c:19](-[c:25]2[n:26][cH:27][c:28]([CH3:31])[cH:29][cH:30]2)[cH:20][c:21]([NH2:22])[cH:23][cH:24]1.[K+:37].[K+:38].[K+:39].[O:42]=[C:43]([CH:44]=[CH:45][c:46]1[cH:47][cH:48][cH:49][cH:50][cH:51]1)[CH:52]=[CH:53][c:54]1[cH:55][cH:56][cH:57][cH:58][cH:59]1.[O:60]=[C:61]([CH:62]=[CH:63][c:64]1[cH:65][cH:66][cH:67][cH:68][cH:69]1)[CH:70]=[CH:71][c:72]1[cH:73][cH:74][cH:75][cH:76][cH:77]1.[O:78]=[C:79]([CH:80]=[CH:81][c:82]1[cH:83][cH:84][cH:85][cH:86][cH:87]1)[CH:88]=[CH:89][c:90]1[cH:91][cH:92][cH:93][cH:94][cH:95]1.[O:96]1[CH2:97][CH2:98][O:99][CH2:100][CH2:101]1.[P:32]([O-:33])([O-:34])([O-:35])=[O:36].[Pd:40].[Pd:41]>>[c:2]1([NH:22][c:21]2[cH:20][c:19](-[c:25]3[n:26][cH:27][c:28]([CH3:31])[cH:29][cH:30]3)[c:18]([CH3:17])[cH:24][cH:23]2)[c:3]2[c:8]([cH:9][cH:10][cH:11]1)[CH2:7][N:6]([CH2:12][C:13]([CH3:14])([F:15])[F:16])[CH2:5][CH2:4]2Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-a5b216ffc3504d549603b2e4921a1dec
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
Loading…