Acetate → Methyl 2-(4-fluoroanilino)-4-methoxybenzoate

HRID 1126389Notes

Reaction equation

HRID 1126389 reaction equation
[C:14](=[O:15])([O-:16])[O-:17].[C:28]([O-:29])(=[O:30])[CH3:31].[C:33]([O-:34])(=[O:35])[CH3:36].[CH3:37][c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1.[Cs+:18].[Cs+:19].[I:1][c:2]1[c:3]([C:4](=[O:5])[O:6][CH3:7])[cH:8][cH:9][c:10]([O:12][CH3:13])[cH:11]1.[NH2:20][c:21]1[cH:22][cH:23][c:24]([F:25])[cH:26][cH:27]1.[Pd+2:32]>>[c:2]1([NH:20][c:21]2[cH:22][cH:23][c:24]([F:25])[cH:26][cH:27]2)[c:3]([C:4](=[O:5])[O:6][CH3:7])[cH:8][cH:9][c:10]([O:12][CH3:13])[cH:11]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 1140TolueneHCID 97314-FluoroanilineHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 54385122Methyl 2-iodo-4-methoxybenzoate

Product 1

HCID 57667822Methyl 2-(4-fluoroanilino)-4-methoxybenzoate

Sources & evidence

ORD record
ord-c1045ecacc374b68b6885561c3055a32
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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