1-[2-(4-Amino-2-chlorophenyl)ethyl]4-trifluoromethylpiperidin-4-ol → 3-(3-Bromobiphenyl-4-yl)propynoic acid-{3-chloro-4-[2-(4-hydroxy-4-trifluoromethylpiperidin-1-yl)ethyl]phenyl}amide
Reaction equation
[Br:1][c:2]1[cH:3][c:4](-[c:13]2[cH:14][cH:15][cH:16][cH:17][cH:18]2)[cH:5][cH:6][c:7]1[C:8]#[C:9][C:10](=[O:11])[OH:12].[NH2:19][c:20]1[cH:21][c:22]([Cl:39])[c:23]([CH2:26][CH2:27][N:28]2[CH2:29][CH2:30][C:31]([OH:34])([C:35]([F:36])([F:37])[F:38])[CH2:32][CH2:33]2)[cH:24][cH:25]1>>[Br:1][c:2]1[cH:3][c:4](-[c:13]2[cH:14][cH:15][cH:16][cH:17][cH:18]2)[cH:5][cH:6][c:7]1[C:8]#[C:9][C:10](=[O:12])[NH:19][c:20]1[cH:21][c:22]([Cl:39])[c:23]([CH2:26][CH2:27][N:28]2[CH2:29][CH2:30][C:31]([OH:34])([C:35]([F:36])([F:37])[F:38])[CH2:32][CH2:33]2)[cH:24][cH:25]1Participants
3
Sources & evidence
- ORD record
- ord-d9f516c9f6294af8bffe1964e00842bc
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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