(3S,4S)-tert-Butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate → tert-butyl (3RS,4RS)-3-hydroxy-4-[4-(4-phenoxy-but-2-ynyloxy)-phenyl]-piperidine-1-carboxylate
Reaction equation
[CH3:22][S:23]([O:24][CH2:27][C:28]#[C:29][CH2:30][O:31][c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1)(=[O:25])=[O:26].[OH:1][CH:2]1[CH2:3][N:4]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:5][CH2:6][CH:7]1[c:8]1[cH:9][cH:10][c:11]([OH:14])[cH:12][cH:13]1>>[OH:1][CH:2]1[CH2:3][N:4]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:5][CH2:6][CH:7]1[c:8]1[cH:9][cH:10][c:11]([O:14][CH2:27][C:28]#[C:29][CH2:30][O:31][c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)[cH:12][cH:13]1Participants
3
Sources & evidence
- ORD record
- ord-7d3092ce70774124bb2f1e8fb5b7dde8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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