HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromoacetyl bromide → 2-[5-(2-Bromoacetyl)-2-ethoxyphenyl]-5-methyl-7-cycloheptyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromoacetyl bromide | HCID 61147 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | HCID 135604935 | HCID 135604935 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-[5-(2-Bromoacetyl)-2-ethoxyphenyl]-5-methyl-7-cycloheptyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one | HCID 135604968 | 66.5% |
Reaction Steps
Analogously to example 57A, 1.36 g (3.7 mmol) of the compound from example 28A were reacted with 1.5 g (7.4 mmol) of bromoacetyl bromide and 1.48 g (1.1 mmol) of aluminum trichloride. Trituration with ether gave 1.2 g (66.3%) of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07098207B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-e437a9002e724c88bacab9094317fea1 |
| Source note | uspto-grants-2006_08 |