1,2,3,4-Tetrahydroisoquinoline → 4-Methyl-2-[-5-(3,4-dihydroisoquinolin-2(1H)-yl)-4'-(trifluoromethyl)biphenyl-3-yl]-pentanoic acid methyl ester
Reaction equation
[CH2:34]1[NH:35][CH2:36][CH2:37][c:38]2[cH:39][cH:40][cH:41][cH:42][c:43]21.[CH3:1][O:2][C:3]([CH:4]([CH2:5][CH:6]([CH3:7])[CH3:8])[c:9]1[cH:10][c:11](-[c:23]2[cH:24][cH:25][c:26]([C:29]([F:30])([F:31])[F:32])[cH:27][cH:28]2)[cH:12][c:13]([O:15][S:16]([C:17]([F:18])([F:19])[F:20])(=[O:21])=[O:22])[cH:14]1)=[O:33]>>[CH3:1][O:2][C:3]([CH:4]([CH2:5][CH:6]([CH3:7])[CH3:8])[c:9]1[cH:10][c:11](-[c:23]2[cH:24][cH:25][c:26]([C:29]([F:30])([F:31])[F:32])[cH:27][cH:28]2)[cH:12][c:13]([N:35]2[CH2:34][c:43]3[c:38]([cH:39][cH:40][cH:41][cH:42]3)[CH2:37][CH2:36]2)[cH:14]1)=[O:33]Participants
3
Sources & evidence
- ORD record
- ord-7a46594b9e0d4f289bd6a416145dbb63
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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