4-Fluorobenzenesulfonyl isocyanate → 1-{3-(7-Cyclopentyl-5-methyl-4-oxo-3,4-dihydroimidazo[5,1-f][1,2,4]-triazin-2-yl)-4-propoxyphenyl}-3-(4-fluorophenylsulfonyl)-urea

Participants

Role	Name	HCID	Charge
Reactant	4-Fluorobenzenesulfonyl isocyanate	HCID 2733374	—
Reactant	2-(5-Amino-2-propoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one	HCID 135604925	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	1-{3-(7-Cyclopentyl-5-methyl-4-oxo-3,4-dihydroimidazo[5,1-f][1,2,4]-triazin-2-yl)-4-propoxyphenyl}-3-(4-fluorophenylsulfonyl)-urea	HCID 135604954	—

Reaction Steps

The preparation is carried out analogously to the procedure of example 54 using 150 mg (0.408 mmol) of the amino compound from example 44A and 411 mg (2.04 mmol) of 4-fluorobenzenesulfonyl isocyanate in 12 ml of tetrahydrofuran, which are reacted overnight.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07098207B2
Source dataset	uspto-grants-2006_08
ORD ID	ord-9b6acc6d97074603b60437d04dd0503a
Source note	uspto-grants-2006_08