Diethyl Ether → N-[3-(4-chlorophenyl)-3-(4-fluorophenyl)3-hydroxypropyl]pipecolic acid methyl ester
Reaction equation
[CH3:10][O:11][C:12]([CH:13]1[N:14]([CH2:19][CH2:20][C:21](=[O:22])[c:23]2[cH:24][cH:25][c:26]([F:29])[cH:27][cH:28]2)[CH2:15][CH2:16][CH2:17][CH2:18]1)=[O:30].[CH3:31][CH2:32][O:33][CH2:34][CH3:35].[Cl:2][c:3]1[cH:4][cH:5][c:6]([Mg+:9])[cH:7][cH:8]1.[I-:1]>>[Cl:2][c:3]1[cH:4][cH:5][c:6]([C:21]([CH2:20][CH2:19][N:14]2[CH:13]([C:12]([O:11][CH3:10])=[O:30])[CH2:18][CH2:17][CH2:16][CH2:15]2)([OH:22])[c:23]2[cH:24][cH:25][c:26]([F:29])[cH:27][cH:28]2)[cH:7][cH:8]1Participants
5
Sources & evidence
- ORD record
- ord-4a06b08687f242888a9f209a190006d7
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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